Biohaven在ASN 2026公布BHV-1420临床前数据，TRAP肾病管线扩展但仍处极早期

One year after
Biohaven's
first TRAP degrader, BHV-1400, was highlighted in the Kidney Week opening plenary,
Biohaven's
second TRAP degrader for kidney disease expands its Yale-licensed platform into a growing nephrology franchise
BHV-1420 is an investigational TRAP™ extracellular protein degrader. It is designed to bind anti-PLA2R autoantibodies, the main driver of disease in most patients with membranous nephropathy, directing them to the liver for degradation without immunosuppression.
In a competitive clinical diagnostic ELISA, BHV-1420 brought 88% of anti-PLA2R-positive patient samples (n=59) below the clinical threshold for positivity.
In a mouse model, a single subcutaneous dose of BHV-1420 rapidly cleared circulating anti-PLA2R antibody in a dose-dependent manner, achieving >90% depletion within two hours that was sustained over the 72-hour test period.
BHV-1420 joins BHV-1400 in IgA nephropathy as the second program in
Biohaven's
TRAP nephrology franchise. Both are built on extracellular protein degrader technology exclusively licensed from
Yale University
.
NEW HAVEN, Conn.
,
Oct. 26, 2026
/PRNewswire/ --
Biohaven Ltd.
(NYSE: BHVN) (
Biohaven
) on Saturday presented preclinical data for BHV-1420 in an oral presentation at the
American Society of Nephrology (ASN) Kidney Week
2026 in
Denver, Colorado
. BHV-1420 is a novel TRAP extracellular protein degrader designed to selectively eliminate the anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies that drive membranous nephropathy (MN).
The presentation continues
Biohaven's
progress at nephrology's largest meeting:
2024:
BHV-1400, the Company's TRAP degrader for IgA nephropathy (IgAN), made its Kidney Week debut with preclinical data.
2025:
With BHV-1400 in clinical studies,
Biohaven's
TRAP degrader approach in IgAN was highlighted in the opening plenary state-of-the-art lecture.
2026:
BHV-1420 takes the podium as the second TRAP degrader in
Biohaven's
nephrology franchise.
"Last year, our TRAP degrader approach to IgA nephropathy was highlighted in the opening plenary at Kidney Week. This year we are back at ASN with BHV-1420, the second TRAP degrader in our nephrology franchise," said
Tova Gardin
, M.D., Chief Translational Officer of
Biohaven
. "Our approach to membranous nephropathy exemplifies the promise of precision immunology to redefine how we treat immune-mediated disease, moving towards a future in which patients can address their disease at its source, free of the burden of broad immunosuppression. It is in many ways the textbook case for our technology. The disease-driving autoantibody is known, it is measured with a routine blood test, and its levels track with disease activity. Yet, patients are still treated with broad immunosuppression. BHV-1420 is designed to selectively remove the autoantibody that drives the disease with no impact on the broader immune system or immunoglobin repertoire. That is the promise of the platform we licensed from Yale and have progressed from the Spiegel laboratory into patients. It is why we see nephrology as a natural home for a franchise of precision degraders."
A Precision Approach to an Antibody-Driven Disease
MN is one of the clearest examples in nephrology of a disease driven by a measurable autoantibody. In most patients with primary MN, autoantibodies attack PLA2R, a protein on podocytes, the specialized cells that maintain the kidney's filtration barrier. This damages the barrier causing heavy protein loss in the urine but also causes an inflammatory immune cascade leading to progressive kidney disease. Anti-PLA2R levels are measured in routine practice and track with disease activity. Yet, current treatment relies on broad immunosuppression with rituximab, cyclophosphamide, calcineurin inhibitors and corticosteroids. Even so, many patients do not achieve or stay in long-term remission which are characterized by the return of the anti-PLA2R autoantibodies.
BHV-1420 is a bispecific molecule designed to work differently. Instead of suppressing the immune cells that make antibodies, it captures and removes the harmful autoantibody itself. One end of the molecule binds anti-PLA2R autoantibodies and the other end binds the asialoglycoprotein receptor (ASGPR), which liver cells use to clear senescent proteins from the blood. The liver cell then takes in the complex and breaks down the autoantibody via the lysosome(Figure 1).
Figure 1.
BHV-1420 mechanism of action. (1) BHV-1420 binds a circulating anti-PLA2R autoantibody (AAb). (2) The complex engages the asialoglycoprotein receptor (ASGPR) on hepatocytes, forming a ternary complex. (3) The autoantibody is internalized and degraded in the lysosome. *Stylistic representation. TRAP, Targeted Removal of Aberrant Protein.
Key Findings Presented at Kidney Week 2026
MECHANISM CONFIRMED IN THE LAB:
BHV-1420 formed the ternary complex (antibody, degrader and ASGPR) needed for degradation and drove ASGPR-dependent uptake of anti-PLA2R antibody into cells.
BROAD COVERAGE OF PATIENT AUTOANTIBODIES:
Patient samples were pre-mixed with BHV-1420 before running a clinical diagnostic anti-PLA2R ELISA. BHV-1420 brought 88% of anti-PLA2R-positive samples tested (n=59) below the threshold for positivity. This indicates it recognizes most of the autoantibodies found in patients (Figure 2). In clinical practice, patients achieve "immunologic remission" of disease when their autoantibodies fall below this threshold of positivity.
RAPID CLEARANCE IN MICE:
Mice received anti-PLA2R antibody at levels similar to those seen in patients, followed by subcutaneous BHV-1420. Circulating anti-PLA2R antibodies fell rapidly and in a dose-dependent manner. At the highest dose (4.8 mg/kg), a single dose of subcutaneous BHV-1420 achieved >90% depletion of circulating anti-PLA2R antibodies within two hours and sustained over the 72-hour study period (Figure 3).
Figure 2.
BHV-1420 competes for patient anti-PLA2R autoantibodies in a clinical diagnostic ELISA. Patient samples were pre-incubated with or without BHV-1420 and transferred to plates coated with recombinant PLA2R; bound autoantibody was detected with an anti-human secondary antibody. BHV-1420 reduced 88% of anti-PLA2R-positive IMN samples tested (n=59) below the clinical diagnostic threshold for positivity. IMN, idiopathic membranous nephropathy; RU, relative units.
Figure 3.
Subcutaneous BHV-1420 depletes circulating anti-PLA2R antibody in a passive transfer mouse model. Anti-PLA2R antibody was administered intravenously at approximately patient-level concentrations, followed one hour later by subcutaneous BHV-1420 (0.5, 1.5 or 4.8 mg/kg) or vehicle; blood was sampled through 72 hours. Line graphs show relevant amounts of anti-PLA2R antibody remaining over a 72-hour study period following subcutaneous BHV-1420 dosing. IV, intravenous; mpk, mg/kg; SC, subcutaneous.
"BHV-1420 shows how modular the TRAP platform is," said
David Pirman
, Ph.D., Executive Vice President and Head of Discovery at
Biohaven
. "We engineered and optimized one end of the molecule to recognize the anti-PLA2R autoantibodies found in patients and the other to hand them off to the liver for degradation. Tested against patient samples in a clinical diagnostic assay, BHV-1420 brought 88% of positive samples below the threshold for positivity. In mice, it rapidly cleared circulating anti-PLA2R antibody after subcutaneous dosing.
Dr. Edward
deRamon and our team have built exactly the profile we set out to engineer."
Built on a Clinically Validated Platform from Yale
BHV-1420 is built on
Biohaven's
extracellular protein degrader platform. The platform came out of Professor
David Spiegel's
laboratory at
Yale University
and has been exclusively licensed to
Biohaven
worldwide since 2021.
HOW TRAP DEGRADERS WORK:
All TRAP degraders use the same ASGPR clearance route. Each one's target-binding end is tailored to a single disease-causing protein and designed to spare healthy antibodies.
CLINICAL VALIDATION:
The lead MoDE™ degrader, BHV-1300, is in a Phase 3 trial in Graves' disease. The lead TRAP degrader, BHV-1400 has produced selective reductions of Gd-IgA1 in patients with IgAN.
Biohaven
continues to evaluate strategic partnerships to extend the platform's reach, including next-generation programs such as BHV-1420.
Presentation Details
Title
Preclinical Characterization of BHV-1420: A Novel TRAP™ Degrader of PLA2R
Autoantibodies for Treatment of Membranous Nephropathy
Presenter
Edward deRamon, Ph.D., Principal Investigator, Medicinal Chemistry,
Biohaven
Session
Preclinical Characterization of BHV-1420: A Novel TRAP Degrader of
Phospholipase A2 Receptor Autoantibodies for Treatment of Membranous
Nephropathy, Presentation Number: SA-OR056
Date and time
Saturday, October 24, 2026
, 4:30 pm MT
Location
Mile High Ballroom
4D,
Colorado Convention Center
,
Denver, Colorado
About Membranous Nephropathy
Membranous nephropathy (MN) is an autoimmune kidney disease and a leading cause of nephrotic syndrome in adults, with an estimated incidence of approximately 1.2 per 100,000 people per year. In 70% to 80% of patients with primary MN, autoantibodies against PLA2R drive the disease. Patients develop protein loss in the urine, swelling, high cholesterol, low blood protein and fatigue. International guidelines use anti-PLA2R autoantibody testing for diagnosis and monitoring. Despite treatment, 30% to 40% of patients do not stay in long-term remission and are at risk of kidney failure. MN can also return after kidney transplantation.
About BHV-1420
BHV-1420 is an investigational TRAP degrader designed to selectively bind circulating anti-PLA2R autoantibodies and direct them to liver cells for degradation. Because it is designed to remove the harmful autoantibody rather than suppress the immune system, BHV-1420 is being developed as a potential first-in-class precision therapy for PLA2R-associated MN. BHV-1420 is in preclinical development. It has not been approved by the
US Food and Drug Administration
or any other regulator, and its safety and efficacy have not been established.
About BHV-1400
BHV-1400 is
Biohaven's
lead TRAP degrader. It is designed to selectively remove galactose-deficient IgA1 (Gd-IgA1), the driver of IgAN, while sparing healthy antibodies. In an ongoing Phase 1b study in patients with IgAN, subcutaneous BHV-1400 reduced Gd-IgA1 by more than 60% on average within 48 hours and by approximately 70% within the first month. There were no clinically significant reductions in IgA, IgG, IgE or IgM. BHV-1400 is investigational and has not been approved by any regulator.
About Biohaven
Biohaven Ltd. is a clinical-stage biopharmaceutical company headquartered in New Haven, Connecticut. It discovers and develops therapies in immunology, obesity, neuroscience and oncology. Its proprietary platforms include MoDE and TRAP extracellular protein degraders for immune-mediated diseases, next-generation ADC platform for oncology, Kv7 ion channel activators for epilepsy, and myostatin-activin pathway inhibitors for neuromuscular and metabolic diseases. For more information, visit
www.biohaven.com
.
Forward-Looking Statements
This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements about the potential of BHV-1420 and other TRAP and MoDE degraders, the future development of Biohaven's degrader programs and the potential for strategic partnerships. Words such as "designed to," "potential," "believe," "may," "will" and "continue" identify forward-looking statements. These statements are not guarantees of future performance and involve risks and uncertainties, including whether preclinical results will be reproduced in humans, whether BHV-1420 advances into clinical development, the outcomes of clinical trials, decisions by the U.S. Food and Drug Administration and other regulators, the availability of funding and partners, and the other risks described in Biohaven's filings with the U.S. Securities and Exchange Commission, including the sections titled "Risk Factors." Forward-looking statements speak only as of the date of this release, and Biohaven undertakes no obligation to update them except as required by law.
MoDE and TRAP are trademarks of Biohaven Therapeutics Ltd.
Investor Contact
Jennifer Porcelli, Vice President, Investor Relations
jennifer.porcelli@biohavenpharma.com
|  +1 (201) 248-0741
Media Contact
Mike Beyer, Sam Brown Inc.
mikebeyer@sambrown.com
|  +1 (312) 961-2502
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