Seeking Alpha 汇总8月底小盘医疗股做空比例，Akanda与Karyopharm居前

Short interest data from late August 2026 highlights deeply divided investor sentiment across small-cap healthcare stocks (market capitalizations up to $2 billion). Heavy bearish bets remain concentrated in high-volatility names like Akanda Corp. ( AKAN ) and Karyopharm Therapeutics ( KPTI ), which carry elevated short interests of 48.84% and 42.51%, respectively. Conversely, lower-profile healthcare companies like MIRA Pharmaceuticals ( MIRA ) and NKGen Biotech ( NKGN ) maintain minimal short exposure, both holding short positions around 0.50%. Overall, short sellers continue to target speculative biotechnology and pharmaceutical players in the under-$2B market cap space, while select niche clinical and technology providers maintain minimal short interest. This cautious positioning aligns with relative weakness across the broader sector. Year-to-date, the S&P 500 has surged 11.48%, whereas the Health Care Select Sector SPDR® Fund ( XLV ) has lagged slightly with a 10.90% gain, dampening broader market momentum given healthcare's 12.1% weighting in the benchmark. Here are the five most shorted healthcare stocks with market capitalizations of up to $2 billion (as a % of shares outstanding) as of August 31: Akanda Corp. ( AKAN ) – Pharmaceuticals | Short Interest: 48.84% Karyopharm Therapeutics ( KPTI ) – Biotechnology | Short Interest: 42.51% LENZ Therapeutics ( LENZ ) – Pharmaceuticals | Short Interest: 35.63% Recursion Pharmaceuticals ( RXRX ) – Biotechnology | Short Interest: 33.24% Intellia Therapeutics ( NTLA ) – Biotechnology | Short Interest: 32.03% Here are the five least shorted healthcare stocks with market capitalizations of up to $2 billion (as a % of shares outstanding) as of August 31: MIRA Pharmaceuticals ( MIRA ) – Pharmaceuticals | Short Interest: 0.50% NKGen Biotech ( NKGN ) – Biotechnology | Short Interest: 0.51% Impact BioMedical ( IBO ) – Pharmaceuticals | Short Interest: 0.51% Veradigm ( MDRX ) – Health Care Technology | Short Interest: 0.52% Bullfrog AI Holdings ( BFRG ) – Health Care Technology | Short Interest: 0.52% Health Care ETFs: ( XLV ), ( VHT ), ( IHI ), ( IXJ ), ( IYH ), ( FHLC ), ( XPH ), ( PPH ), ( IBB ), ( IHE ), ( IBBQ ) and ( FXH ) .