阿斯利康/安进Tezspire治疗嗜酸性食管炎III期CROSSING详细数据在UEGW公布，但阳性顶线结果8月底已官宣，属旧闻再报道

On Tuesday, AstraZeneca (AZN) and Amgen (AMGN) said Tezspire met both co-primary and key secondary endpoints in the Phase 3 CROSSING trial in eosinophilic esophagitis, with improvements at week 24 sustained through week 52.
Eosinophilic Esophagitis (EoE) & Tezspire
Eosinophilic esophagitis is a chronic inflammatory disorder of the esophagus that can cause difficulty swallowing and food becoming stuck. Tezspire, or tezepelumab, is a monoclonal antibody that blocks thymic stromal lymphopoietin, a protein involved in inflammation.
CROSSING Trial Details
The randomized, double-blind trial enrolled 368 patients aged 12-80 years with symptomatic and histologically active disease. Patients received Tezspire 210 mg, 420 mg or placebo by subcutaneous injection every four weeks.
The co-primary endpoints at week 24 were histologic remission, defined as an esophageal eosinophil count of six or fewer per high-power field, and changes in difficulty-swallowing symptoms measured by the Dysphagia Symptom Questionnaire.
Key secondary endpoints included remission and swallowing symptoms at week 52, changes in endoscopic and tissue-level disease severity at weeks 24 and 52, and endoscopic remission at week 52.
Trial Results
At week 24, histologic remission was achieved by 64.8% and 68.9% of patients receiving the 210 mg and 480 mg Tezspire doses, compared with 3.5% receiving placebo.
Difficulty-swallowing symptom scores declined by 18.8 and 22.0 points, respectively, versus 14.7 points with placebo, meeting the other co-primary endpoint.
At week 52, histologic remission rates were 67.8% and 63.3%, versus 5.4% with placebo. Total endoscopic remission, indicating no visible disease features, was achieved by 34.4% and 29.5%, respectively, compared with 4.1%.
The safety profile was consistent with Tezspire's approved indications. The most frequently reported adverse events were nasopharyngitis, headache and diarrhea.
The findings were presented at United European Gastroenterology Week 2026, held October 17-20, 2026, in Barcelona, Spain.
AZN is trading up 2.24% at $167.65.
AMGN is trading at $434.67, up 2.29%.
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